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PerMedCoE webinar: Biomedicine, supercomputers and simulations: in silico experiments and its applications in cancer research
The PerMedCoE webinar series aims to present and discuss topics and best practices in the field of personalized medicine. All PerMedCoE webinars include an audience Q&A session during which attendees can ask questions and make suggestions. Please note that all webinars are recorded and available for posterior viewing.

Computational simulations of cellular processes are critical tools to formulate mechanistic explanations that facilitate the interpretation of experimental results. However, complex biological processes such as tumour evolution span across different time-space scales. In this context, multi-scale models are ideal tools to address systems biology questions as they can consider several time-space scales by combining different approaches into a hybrid simulation.
PhysiCell is an open-source, agent-based extensible multi-scale modelling framework that allows simulating complex multicellular systems such as healthy tissues and tumours. At the lowest scale, PhysiCell uses BioFVM solver to simulate the cellular chemical microenvironment processes using partial differential equations. At the cell scale, PhysiCell uses mechanical equations to model individual cell movement, cell-cell or cell-microenvironment interactions. Additionally, different cells types and heterogeneous populations can be defined by user-defined submodels.
Furthermore, PhysiBoSS is an addon-based extension of PhysiCell that provides cell agents with more complex intracellular networks, such as individual Boolean models of regulatory networks which are simulated using the MaBoSS algorithm. Altogether, PhysiBoSS bridges intracellular dynamics to the population level.
In this webinar, we will introduce the basic concepts of the PhysiCell/PhysiBoSS modelling framework and its HPC-based implementation that can be applied to a broad range of biological problems including cancer, immunology, and microbial ecology.

Speaker: Miguel Ponce de León, Barcelona Supercomputing Center

Dec 14, 2021 03:00 PM in Brussels

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